prof.dr. J. Prakash (Jai)

Hoogleraar - Engineered Therapeutics


Stellate Crystal
Medicine & Life Sciences
Cancer-Associated Fibroblasts
Hepatic Stellate Cells
Liver Cirrhosis
Pancreatic Stellate Cells


  • ScarTec Therapeutics
    ScarTec Therapeutics


Muntean, C., Blondeel, E., Harinck, L., Pednekar, K. , Prakash, J., De Wever, O., Chain, J. L., De Smedt, S. C., Remaut, K., & Raemdonck, K. (2023). Repositioning the antihistamine ebastine as an intracellular siRNA delivery enhancer. International journal of pharmaceutics, 644, [123348]. https://doi.org/10.1016/j.ijpharm.2023.123348
Biancacci, I., De Santis, D., Rama, E., Benderski, K., Momoh, J., Pohlberger, R., Moeckel, D., Kaps, L., Rijcken, C. J. F. , Prakash, J., Thewissen, M., Kiessling, F., Shi, Y., Peña, Q., Sofias, A. M., Consolino, L. , & Lammers, T. (2023). Repurposing Tamoxifen for Tumor Microenvironment Priming and Enhanced Tumor-Targeted Drug Delivery. Advanced Therapeutics. https://doi.org/10.1002/adtp.202300098
Priwitaningrum, D. L. (2023). Strategies to overcome barriers for cancer (nano)medicines. [PhD Thesis - Research UT, graduation UT, University of Twente]. University of Twente. https://doi.org/10.3990/1.9789036556163
Kurniawan, D. W. , Booijink, R. S., Jajoriya, A. K., Dhawan, G., Mishra, D., Oosterhuis, D., Argemi, J. , Storm, G., Olinga, P., Bataller, R., Mohanty, S. K., Mishra, D. P. , Prakash, J. , & Bansal, R. (2022). Src kinase as a potential therapeutic target in non-alcoholic and alcoholic steatohepatitis. Clinical and translational discovery, 2(1), [e18]. https://doi.org/10.1002/ctd2.18
Prakash, J. (2022). The Tumor Stroma: Key Component of Solid Tumors. In J. Prakash (Ed.), The Tumor Stroma: Biology and Therapeutics https://doi.org/10.1201/9781003224921-1
Pednekar, K. , Heinrich, M. A. , & Prakash, J. (2022). Role of Integrins in the Tumor Stroma. In J. Prakash (Ed.), The Tumor Stroma: Biology and Therapeutics https://doi.org/10.1201/9781003224921-7
Lu, T. , Terstappen, L. W. M. M. , & Prakash, J. (2022). MicroRNA in the Tumor Stroma: Diagnostic and Therapeutic Implications. In J. Prakash (Ed.), The Tumor Stroma: Biology and Therapeutics (1 ed.). Jenny Stanford Publishing. https://doi.org/10.1201/9781003224921-8
Alexander, M., Huynh, N. T., Zhang, Y. S. , & Prakash, J. (2022). 3D in vitro Models to Mimic the Tumor Microenvironment. In J. Prakash (Ed.), The Tumor Stroma: Biology and Therapeutics Taylor & Francis. https://doi.org/10.1201/9781003224921-10
Uboldi, I., Poduval, P. , & Prakash, J. (2022). Engineering solutions to design CAR-T cells. In Engineering Technologies and Clinical Translation: Volume 3 of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy (pp. 1-31). Elsevier. https://doi.org/10.1016/B978-0-323-90949-5.00001-2
Rimal, R., Desai, P., Daware, R., Hosseinnejad, A. , Prakash, J. , Lammers, T., & Singh, S. (2022). Cancer-associated fibroblasts: Origin, function, imaging, and therapeutic targeting. Advanced drug delivery reviews, 189, [114504]. https://doi.org/10.1016/j.addr.2022.114504
Day, N. B., Dalhuisen, R., Loomis, N. E., Adzema, S. G. , Prakash, J., & Shields IV, C. W. (2022). Tissue-adhesive hydrogel for multimodal drug release to immune cells in skin. Acta biomaterialia, 150, 211-220. https://doi.org/10.1016/j.actbio.2022.07.053
Calejo, I. , Heinrich, M. A., Zambito, G., Mezzanotte, L. , Prakash, J. , & Teixeira, L. M. (2022). Advancing Tumor Microenvironment Research by Combining Organs-on-Chips and Biosensors. In D. Caballero, S. C. Kundu, & R. L. Reis (Eds.), Microfluidics and Biosensors in Cancer Research: Applications in Cancer Modeling and Theranostics (pp. 171-203). (Advances in Experimental Medicine and Biology; Vol. 1379). Springer. https://doi.org/10.1007/978-3-031-04039-9_7
Kurniawan, D. W. (2022). Targeting of macrophages and hepatic stellate cells for the treatment of liver diseases. [PhD Thesis - Research UT, graduation UT, University of Twente]. University of Twente. https://doi.org/10.3990/1.9789036553445
Mardhian, D. F. (2022). Designing novel therapeutic strategies against tumor stroma and fibrosis. [PhD Thesis - Research UT, graduation UT, University of Twente]. University of Twente. https://doi.org/10.3990/1.9789036553179

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In de Pers

Volkskrant Newspaper (Sep 2019): Verzwakte muur om kankercellen biedt chemo een kans. https://www.volkskrant.nl/cs-bf0bd786

Tubantia Newspaper,   “UT sets new steps in the treatment of pancreatic cancer”, 10 Nov 2017. https://www.tubantia.nl/regio/ut-zet-flinke-stappen-in-behandeling-alvleesklierkanker~a2caecdc/

U-Today, Science and Technology magazine  “Novel treatment to kill cancer by targeting stroma” Oct, 2017. https://www.utoday.nl/science/64599/unique-treatment-from-twente-effectively-kills-cancer

“KNCV Golden Master award 2017” to Marcel Heinrich (PhD student under my supervision), for his master project in my group on "Lipids against Cancer". https://www.c2w.nl/verenigingen-8751/lipide-tegen-kanker/item19184

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