prof.dr. J. Prakash (Jai)

Hoogleraar - Engineered Therapeutics
TNW-BET-AOT
Horst - Zuidhorst 246
j.prakash@utwente.nl
+31534893096
Visitekaartje

Expertises

  • Pharmacology, Toxicology and Pharmaceutical Science

    • Neoplasm
    • Malignant Neoplasm

  • Medicine and Dentistry

    • Combination Therapy
    • Stroma
    • Peptide
    • Cells

  • Biochemistry, Genetics and Molecular Biology

    • Fibroblast
    • Integrin

Organisaties

Nevenwerkzaakheden

  • ScarTec TherapeuticsManagement of ScarTec Therapeutics

Publicaties

Jump to: 2024 | 2023 | 2022

2024

The Interplay between Extracellular Matrix Remodeling and Cancer Therapeutics (2024)Cancer Discovery, 14(8), 1375-1388. Prakash, J. & Shaked, Y.https://doi.org/10.1158/2159-8290.CD-24-0002Novel targeting strategies to reprogram cancer-associated fibroblasts in the tumor microenvironment (2024)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Mostafa, A. M. R. H.https://doi.org/10.3990/1.9789036561334Polymeric nanofiber leveraged co-delivery of anti-stromal PAK1 inhibitor and paclitaxel enhances therapeutic effects in stroma-rich 3D spheroid models (2024)International journal of pharmaceutics, 656. Article 124078. M.R.H. Mostafa, A., Petrai, O., Poot, A. A. & Prakash, J.https://doi.org/10.1016/j.ijpharm.2024.124078Corrigendum to “Tissue-adhesive hydrogel for multimodal drug release to immune cells in skin” [Acta Biomaterialia Volume 150, Pages 211–220] (Acta Biomaterialia (2022) 150 (211–220), (S174270612200455X), (10.1016/j.actbio.2022.07.053)) (2024)Acta biomaterialia, 179, 398-398. Day, N. B., Dalhuisen, R., Loomis, N. E., Adzema, S. G., Prakash, J. & Shields, C. W.https://doi.org/10.1016/j.actbio.2024.04.004Understanding glioblastoma stromal barriers against NK cell attack using tri-culture 3D spheroid model (2024)Heliyon, 10(3). Article e24808. Heinrich, M. A., Huynh, N. T., Heinrich, L. & Prakash, J.https://doi.org/10.1016/j.heliyon.2024.e24808Retraction: Interferon gamma peptidomimetic targeted to interstitial myofibroblasts attenuates renal fibrosis after unilateral ureteral obstruction in mice (2024)Oncotarget, 15, 35. Poosti, F., Bansal, R., Yazdani, S., Prakash, J., Beljaars, L., van den Born, J., de Borst, M. H., van Goor, H., Hillebrands, J. L. & Poelstra, K.https://doi.org/10.18632/oncotarget.28532

2023

Repurposing Tamoxifen for Tumor Microenvironment Priming and Enhanced Tumor-Targeted Drug Delivery (2023)Advanced Therapeutics, 6(11). Article 2300098. Biancacci, I., De Santis, D., Rama, E., Benderski, K., Momoh, J., Pohlberger, R., Moeckel, D., Kaps, L., Rijcken, C. J. F., Prakash, J., Thewissen, M., Kiessling, F., Shi, Y., Peña, Q., Sofias, A. M., Consolino, L. & Lammers, T.https://doi.org/10.1002/adtp.202300098Repositioning the antihistamine ebastine as an intracellular siRNA delivery enhancer (2023)International journal of pharmaceutics, 644. Article 123348. Muntean, C., Blondeel, E., Harinck, L., Pednekar, K., Prakash, J., De Wever, O., Chain, J. L., De Smedt, S. C., Remaut, K. & Raemdonck, K.https://doi.org/10.1016/j.ijpharm.2023.123348INTEGRIN BINDING PEPTIDE AND USE OF THE SAME (2023)[Patent › Patent]. Prakash, J.Strategies to overcome barriers for cancer (nano)medicines (2023)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Priwitaningrum, D. L.https://doi.org/10.3990/1.9789036556163Evaluation of paclitaxel-loaded polymeric nanoparticles in 3D tumor model: impact of tumor stroma on penetration and efficacy (2023)Drug delivery and translational research, 13(5), 1470-1483. Priwitaningrum, D. L., Pednekar, K., Gabriël, A. V., Varela-Moreira, A. A., Gac, S. L., Vellekoop, I., Storm, G., Hennink, W. E. & Prakash, J.https://doi.org/10.1007/s13346-023-01310-1NANOTME2023 Abstract Book: 2nd International Conference on NANOMEDICINE meets the TUMOR MICROENVIRONMENT (2023)[Book/Report › Book editing] (In preparation). Prakash, J. & ten Hoopen, H. W. M.https://doi.org/10.3990/1.9789036556088Microarchitectural mimicking of stroma-induced vasculature compression in pancreatic tumors using a 3D engineered model (2023)Bioactive Materials, 22, 18-33. Heinrich, M. A., Uboldi, I., Kuninty, P. R., Ankone, M. J. K., van Baarlen, J., Zhang, Y. S., Jain, K. & Prakash, J.https://doi.org/10.1016/j.bioactmat.2022.09.015In Vivo Detection of Circulating Cancer-Associated Fibroblasts in Breast Tumor Mouse Xenograft: Impact of Tumor Stroma and Chemotherapy (2023)Cancers, 15(4). Article 1127. Lu, T., Oomens, L., Terstappen, L. W. M. M. & Prakash, J.https://doi.org/10.3390/cancers15041127Endotoxin contamination alters macrophage-cancer cell interaction and therapeutic efficacy in pre-clinical 3D in vitro models (2023)Biomaterials Advances, 144. Article 213220. Heinrich, M. A., Heinrich, L., Ankone, M. J. K., Vergauwen, B. & Prakash, J.https://doi.org/10.1016/j.bioadv.2022.213220

2022

Cancer immune therapy using engineered ‛tail-flipping’ nanoliposomes targeting alternatively activated macrophages (2022)Nature communications, 13(1). Article 4548. Kuninty, P. R., Binnemars-Postma, K., Jarray, A., Pednekar, K. P., Heinrich, M. A., Pijffers, H. J., ten Hoopen, H., Storm, G., van Hoogevest, P., den Otter, W. K. & Prakash, J.https://doi.org/10.1038/s41467-022-32091-9Cancer-associated fibroblasts: Origin, function, imaging, and therapeutic targeting (2022)Advanced drug delivery reviews, 189. Article 114504. Rimal, R., Desai, P., Daware, R., Hosseinnejad, A., Prakash, J., Lammers, T. & Singh, S.https://doi.org/10.1016/j.addr.2022.114504Managing microenvironments: Time to engineer medicines (2022)[Book/Report › Inaugural speech]. University of Twente. Prakash, J.Tissue-adhesive hydrogel for multimodal drug release to immune cells in skin (2022)Acta biomaterialia, 150, 211-220. Day, N. B., Dalhuisen, R., Loomis, N. E., Adzema, S. G., Prakash, J. & Shields IV, C. W.https://doi.org/10.1016/j.actbio.2022.07.053Mimicking tumor microenvironment by 3D bioprinting: 3D cancer modeling (2022)Biofabrication, 14(3). Article 032002. Shukla, P., Yeleswarapu, S., Heinrich, M. A., Prakash, J. & Pati, F.https://doi.org/10.1088/1758-5090/ac6d11Targeting of macrophages and hepatic stellate cells for the treatment of liver diseases (2022)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Kurniawan, D. W.https://doi.org/10.3990/1.9789036553445Impact of endotoxins on bioengineered tissues and models (2022)Trends in biotechnology, 40(5), 532-534. Heinrich, M. A., Mangia, M. & Prakash, J.https://doi.org/10.1016/j.tibtech.2021.12.001Designing novel therapeutic strategies against tumor stroma and fibrosis (2022)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Mardhian, D. F.https://doi.org/10.3990/1.9789036553179Src kinase as a potential therapeutic target in non-alcoholic and alcoholic steatohepatitis (2022)Clinical and translational discovery, 2(1). Article e18. Kurniawan, D. W., Booijink, R. S., Jajoriya, A. K., Dhawan, G., Mishra, D., Oosterhuis, D., Argemi, J., Storm, G., Olinga, P., Bataller, R., Mohanty, S. K., Mishra, D. P., Prakash, J. & Bansal, R.https://doi.org/10.1002/ctd2.18Engineering the tumor microenvironment: Novel 3D in vitro models to study cellular interactions & therapeutics (2022)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Heinrich, M. A.https://doi.org/10.3990/1.9789036553162

Onderzoeksprofielen

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Vakken collegejaar 2024/2025

Vakken in het huidig collegejaar worden toegevoegd op het moment dat zij definitief zijn in het Osiris systeem. Daarom kan het zijn dat de lijst nog niet compleet is voor het gehele collegejaar.

Vakken collegejaar 2023/2024

In de pers

Volkskrant Newspaper (Sep 2019): Verzwakte muur om kankercellen biedt chemo een kans. https://www.volkskrant.nl/cs-bf0bd786

Tubantia Newspaper,   “UT sets new steps in the treatment of pancreatic cancer”, 10 Nov 2017. https://www.tubantia.nl/regio/ut-zet-flinke-stappen-in-behandeling-alvleesklierkanker~a2caecdc/

U-Today, Science and Technology magazine  “Novel treatment to kill cancer by targeting stroma” Oct, 2017. https://www.utoday.nl/science/64599/unique-treatment-from-twente-effectively-kills-cancer

“KNCV Golden Master award 2017” to Marcel Heinrich (PhD student under my supervision), for his master project in my group on "Lipids against Cancer". https://www.c2w.nl/verenigingen-8751/lipide-tegen-kanker/item19184

Nieuws op utwente.nl

Perspectief Op Effectievere Behandeling Alsvleesklierkanker

https://www.utwente.nl/nieuws/2019/9/512858/perspectief-op-effectievere-behandeling-alvleesklierkanker

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