prof.dr. J. Prakash (Jai)

Chemistry

# Drug
# Stellate Crystal

Medicine & Life Sciences

# Cancer-Associated Fibroblasts
# Fibrosis
# Hepatic Stellate Cells
# Liver Cirrhosis
# Neoplasms
# Pancreatic Stellate Cells

Faculty of Science and Technology (TNW), Advanced Organ bioengineering and Therapeutics (AOT)

ScarTec Therapeutics
Management of ScarTec Therapeutics

Poosti, F. , Bansal, R. , Yazdani, S. , Prakash, J., Beljaars, L., van den Born, J., de Borst, M. H., van Goor, H., Hillebrands, J. L., & Poelstra, K. (2024). Retraction: Interferon gamma peptidomimetic targeted to interstitial myofibroblasts attenuates renal fibrosis after unilateral ureteral obstruction in mice. Oncotarget, 15, 35. https://doi.org/10.18632/oncotarget.28532

Prakash, J. (2023). INTEGRIN BINDING PEPTIDE AND USE OF THE SAME. (Patent No. JP2023093473).

Muntean, C., Blondeel, E., Harinck, L., Pednekar, K. , Prakash, J., De Wever, O., Chain, J. L., De Smedt, S. C., Remaut, K., & Raemdonck, K. (2023). Repositioning the antihistamine ebastine as an intracellular siRNA delivery enhancer. International journal of pharmaceutics, 644, Article 123348. https://doi.org/10.1016/j.ijpharm.2023.123348

Biancacci, I., De Santis, D., Rama, E., Benderski, K., Momoh, J., Pohlberger, R., Moeckel, D., Kaps, L., Rijcken, C. J. F. , Prakash, J., Thewissen, M., Kiessling, F., Shi, Y., Peña, Q., Sofias, A. M., Consolino, L. , & Lammers, T. (2023). Repurposing Tamoxifen for Tumor Microenvironment Priming and Enhanced Tumor-Targeted Drug Delivery. Advanced Therapeutics, 6(11), Article 2300098. https://doi.org/10.1002/adtp.202300098

Priwitaningrum, D. L. (2023). Strategies to overcome barriers for cancer (nano)medicines. [PhD Thesis - Research UT, graduation UT, University of Twente]. University of Twente. https://doi.org/10.3990/1.9789036556163

Prakash, J. , & ten Hoopen, H. W. M. (Eds.) (2023). NANOTME2023 Abstract Book: 2nd International Conference on NANOMEDICINE meets the TUMOR MICROENVIRONMENT. https://doi.org/10.3990/1.9789036556088

Priwitaningrum, D. L., Pednekar, K., Gabriël, A. V., Varela-Moreira, A. A. , Gac, S. L. , Vellekoop, I. , Storm, G., Hennink, W. E. , & Prakash, J. (2023). Evaluation of paclitaxel-loaded polymeric nanoparticles in 3D tumor model: impact of tumor stroma on penetration and efficacy. Drug delivery and translational research, 13(5), 1470-1483. https://doi.org/10.1007/s13346-023-01310-1

Lu, T. , Oomens, L. , Terstappen, L. W. M. M. , & Prakash, J. (2023). In Vivo Detection of Circulating Cancer-Associated Fibroblasts in Breast Tumor Mouse Xenograft: Impact of Tumor Stroma and Chemotherapy. Cancers, 15(4), Article 1127. https://doi.org/10.3390/cancers15041127

Heinrich, M. A., Heinrich, L. , Ankone, M. J. K., Vergauwen, B. , & Prakash, J. (2023). Endotoxin contamination alters macrophage-cancer cell interaction and therapeutic efficacy in pre-clinical 3D in vitro models. Biomaterials Advances, 144, Article 213220. https://doi.org/10.1016/j.bioadv.2022.213220

Heinrich, M. A., Uboldi, I. , Kuninty, P. R. , Ankone, M. J. K., van Baarlen, J., Zhang, Y. S. , Jain, K. , & Prakash, J. (2023). Microarchitectural mimicking of stroma-induced vasculature compression in pancreatic tumors using a 3D engineered model. Bioactive Materials, 22, 18-33. https://doi.org/10.1016/j.bioactmat.2022.09.015

Prakash, J. (2022). Managing microenvironments: Time to engineer medicines. University of Twente.

Kurniawan, D. W. , Booijink, R. S., Jajoriya, A. K., Dhawan, G., Mishra, D., Oosterhuis, D., Argemi, J. , Storm, G., Olinga, P., Bataller, R., Mohanty, S. K., Mishra, D. P. , Prakash, J. , & Bansal, R. (2022). Src kinase as a potential therapeutic target in non-alcoholic and alcoholic steatohepatitis. Clinical and translational discovery, 2(1), Article e18. https://doi.org/10.1002/ctd2.18

Prakash, J. (2022). The Tumor Stroma: Key Component of Solid Tumors. In J. Prakash (Ed.), The Tumor Stroma: Biology and Therapeutics https://doi.org/10.1201/9781003224921-1

Prakash, J. (Ed.) (2022). The Tumor Stroma: Biology and Therapeutics. https://doi.org/10.1201/9781003224921

Pednekar, K. , Heinrich, M. A. , & Prakash, J. (2022). Role of Integrins in the Tumor Stroma. In J. Prakash (Ed.), The Tumor Stroma: Biology and Therapeutics https://doi.org/10.1201/9781003224921-7

Bhut, Z. , Heinrich, M. A. , & Prakash, J. (2022). Physical Properties of the Tumor Stroma and Therapeutic Strategies. In J. Prakash (Ed.), The Tumor Stroma: Biology and Therapeutics https://doi.org/10.1201/9781003224921-5

Lu, T. , Terstappen, L. W. M. M. , & Prakash, J. (2022). MicroRNA in the Tumor Stroma: Diagnostic and Therapeutic Implications. In J. Prakash (Ed.), The Tumor Stroma: Biology and Therapeutics (1 ed.). Jenny Stanford Publishing. https://doi.org/10.1201/9781003224921-8

Alexander, M., Huynh, N. T., Zhang, Y. S. , & Prakash, J. (2022). 3D in vitro Models to Mimic the Tumor Microenvironment. In J. Prakash (Ed.), The Tumor Stroma: Biology and Therapeutics Taylor & Francis. https://doi.org/10.1201/9781003224921-10

Uboldi, I., Poduval, P. , & Prakash, J. (2022). Engineering solutions to design CAR-T cells. In Engineering Technologies and Clinical Translation: Volume 3 of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy (pp. 1-31). Elsevier. https://doi.org/10.1016/B978-0-323-90949-5.00001-2

Rimal, R., Desai, P., Daware, R., Hosseinnejad, A. , Prakash, J. , Lammers, T., & Singh, S. (2022). Cancer-associated fibroblasts: Origin, function, imaging, and therapeutic targeting. Advanced drug delivery reviews, 189, Article 114504. https://doi.org/10.1016/j.addr.2022.114504

Day, N. B., Dalhuisen, R., Loomis, N. E., Adzema, S. G. , Prakash, J., & Shields IV, C. W. (2022). Tissue-adhesive hydrogel for multimodal drug release to immune cells in skin. Acta biomaterialia, 150, 211-220. https://doi.org/10.1016/j.actbio.2022.07.053

Kuninty, P. R. , Binnemars-Postma, K. , Jarray, A., Pednekar, K. P. , Heinrich, M. A., Pijffers, H. J. , ten Hoopen, H. , Storm, G., van Hoogevest, P. , den Otter, W. K. , & Prakash, J. (2022). Cancer immune therapy using engineered ‛tail-flipping’ nanoliposomes targeting alternatively activated macrophages. Nature communications, 13(1), Article 4548. https://doi.org/10.1038/s41467-022-32091-9

Shukla, P., Yeleswarapu, S. , Heinrich, M. A. , Prakash, J., & Pati, F. (2022). Mimicking tumor microenvironment by 3D bioprinting: 3D cancer modeling. Biofabrication, 14(3), Article 032002. https://doi.org/10.1088/1758-5090/ac6d11

Calejo, I. , Heinrich, M. A., Zambito, G., Mezzanotte, L. , Prakash, J. , & Teixeira, L. M. (2022). Advancing Tumor Microenvironment Research by Combining Organs-on-Chips and Biosensors. In D. Caballero, S. C. Kundu, & R. L. Reis (Eds.), Microfluidics and Biosensors in Cancer Research: Applications in Cancer Modeling and Theranostics (pp. 171-203). (Advances in Experimental Medicine and Biology; Vol. 1379). Springer. https://doi.org/10.1007/978-3-031-04039-9_7

Kurniawan, D. W. (2022). Targeting of macrophages and hepatic stellate cells for the treatment of liver diseases. [PhD Thesis - Research UT, graduation UT, University of Twente]. University of Twente. https://doi.org/10.3990/1.9789036553445

Naar mijn profiel

Bachelor

Biomedische Technologie

Master

Vakken in het huidig collegejaar worden toegevoegd op het moment dat zij definitief zijn in het Osiris systeem. Daarom kan het zijn dat de lijst nog niet compleet is voor het gehele collegejaar.

Volkskrant Newspaper (Sep 2019): Verzwakte muur om kankercellen biedt chemo een kans. https://www.volkskrant.nl/cs-bf0bd786

Tubantia Newspaper, “UT sets new steps in the treatment of pancreatic cancer”, 10 Nov 2017. https://www.tubantia.nl/regio/ut-zet-flinke-stappen-in-behandeling-alvleesklierkanker~a2caecdc/

U-Today, Science and Technology magazine “Novel treatment to kill cancer by targeting stroma” Oct, 2017. https://www.utoday.nl/science/64599/unique-treatment-from-twente-effectively-kills-cancer

“KNCV Golden Master award 2017” to Marcel Heinrich (PhD student under my supervision), for his master project in my group on "Lipids against Cancer". https://www.c2w.nl/verenigingen-8751/lipide-tegen-kanker/item19184

Perspectief Op Effectievere Behandeling Alsvleesklierkanker

https://www.utwente.nl/nieuws/2019/9/512858/perspectief-op-effectievere-behandeling-alvleesklierkanker

+31534893096

+31534892968 (bij geen gehoor)

j.prakash@utwente.nl

www.utwente.nl/en/tnw/bst/people/scientific/prakash/