prof.dr. J. Prakash (Jai)

Hoogleraar - Engineered Therapeutics
TNW-BET-AOT
Horst - Zuidhorst 246
j.prakash@utwente.nl
+31534893096
Visitekaartje

Expertises

  • Pharmacology, Toxicology and Pharmaceutical Science

    • Neoplasm
    • Malignant Neoplasm

  • Medicine and Dentistry

    • Combination Therapy
    • Stroma
    • Peptide
    • Cells

  • Biochemistry, Genetics and Molecular Biology

    • Fibroblast
    • Integrin

Organisaties

Nevenwerkzaakheden

  • ScarTec TherapeuticsManagement of ScarTec Therapeutics

Publicaties

2024
Polymeric nanofiber leveraged co-delivery of anti-stromal PAK1 inhibitor and paclitaxel enhances therapeutic effects in stroma-rich 3D spheroid models, Article 124078. M.R.H. Mostafa, A., Petrai, O., Poot, A. A. & Prakash, J.https://doi.org/10.1016/j.ijpharm.2024.124078Corrigendum to “Tissue-adhesive hydrogel for multimodal drug release to immune cells in skin” [Acta Biomaterialia Volume 150, Pages 211–220] (Acta Biomaterialia (2022) 150 (211–220), (S174270612200455X), (10.1016/j.actbio.2022.07.053)), 398-398. Day, N. B., Dalhuisen, R., Loomis, N. E., Adzema, S. G., Prakash, J. & Shields, C. W.https://doi.org/10.1016/j.actbio.2024.04.004Understanding glioblastoma stromal barriers against NK cell attack using tri-culture 3D spheroid model, Article e24808. Heinrich, M. A., Huynh, N. T., Heinrich, L. & Prakash, J.https://doi.org/10.1016/j.heliyon.2024.e24808Retraction: Interferon gamma peptidomimetic targeted to interstitial myofibroblasts attenuates renal fibrosis after unilateral ureteral obstruction in mice, 35. Poosti, F., Bansal, R., Yazdani, S., Prakash, J., Beljaars, L., van den Born, J., de Borst, M. H., van Goor, H., Hillebrands, J. L. & Poelstra, K.https://doi.org/10.18632/oncotarget.28532
2023
Repurposing Tamoxifen for Tumor Microenvironment Priming and Enhanced Tumor-Targeted Drug Delivery, Article 2300098. Biancacci, I., De Santis, D., Rama, E., Benderski, K., Momoh, J., Pohlberger, R., Moeckel, D., Kaps, L., Rijcken, C. J. F., Prakash, J., Thewissen, M., Kiessling, F., Shi, Y., Peña, Q., Sofias, A. M., Consolino, L. & Lammers, T.https://doi.org/10.1002/adtp.202300098Repositioning the antihistamine ebastine as an intracellular siRNA delivery enhancer, Article 123348. Muntean, C., Blondeel, E., Harinck, L., Pednekar, K., Prakash, J., De Wever, O., Chain, J. L., De Smedt, S. C., Remaut, K. & Raemdonck, K.https://doi.org/10.1016/j.ijpharm.2023.123348INTEGRIN BINDING PEPTIDE AND USE OF THE SAME. Prakash, J.Strategies to overcome barriers for cancer (nano)medicines. University of Twente. Priwitaningrum, D. L.https://doi.org/10.3990/1.9789036556163Evaluation of paclitaxel-loaded polymeric nanoparticles in 3D tumor model: impact of tumor stroma on penetration and efficacy, 1470-1483. Priwitaningrum, D. L., Pednekar, K., Gabriël, A. V., Varela-Moreira, A. A., Gac, S. L., Vellekoop, I., Storm, G., Hennink, W. E. & Prakash, J.https://doi.org/10.1007/s13346-023-01310-1NANOTME2023 Abstract Book: 2nd International Conference on NANOMEDICINE meets the TUMOR MICROENVIRONMENT (In preparation). Prakash, J. & ten Hoopen, H. W. M.https://doi.org/10.3990/1.9789036556088Microarchitectural mimicking of stroma-induced vasculature compression in pancreatic tumors using a 3D engineered model, 18-33. Heinrich, M. A., Uboldi, I., Kuninty, P. R., Ankone, M. J. K., van Baarlen, J., Zhang, Y. S., Jain, K. & Prakash, J.https://doi.org/10.1016/j.bioactmat.2022.09.015In Vivo Detection of Circulating Cancer-Associated Fibroblasts in Breast Tumor Mouse Xenograft: Impact of Tumor Stroma and Chemotherapy, Article 1127. Lu, T., Oomens, L., Terstappen, L. W. M. M. & Prakash, J.https://doi.org/10.3390/cancers15041127Endotoxin contamination alters macrophage-cancer cell interaction and therapeutic efficacy in pre-clinical 3D in vitro models, Article 213220. Heinrich, M. A., Heinrich, L., Ankone, M. J. K., Vergauwen, B. & Prakash, J.https://doi.org/10.1016/j.bioadv.2022.213220
2022
Cancer immune therapy using engineered ‛tail-flipping’ nanoliposomes targeting alternatively activated macrophages, Article 4548. Kuninty, P. R., Binnemars-Postma, K., Jarray, A., Pednekar, K. P., Heinrich, M. A., Pijffers, H. J., ten Hoopen, H., Storm, G., van Hoogevest, P., den Otter, W. K. & Prakash, J.https://doi.org/10.1038/s41467-022-32091-9Cancer-associated fibroblasts: Origin, function, imaging, and therapeutic targeting, Article 114504. Rimal, R., Desai, P., Daware, R., Hosseinnejad, A., Prakash, J., Lammers, T. & Singh, S.https://doi.org/10.1016/j.addr.2022.114504Managing microenvironments: Time to engineer medicines. University of Twente. Prakash, J.Tissue-adhesive hydrogel for multimodal drug release to immune cells in skin, 211-220. Day, N. B., Dalhuisen, R., Loomis, N. E., Adzema, S. G., Prakash, J. & Shields IV, C. W.https://doi.org/10.1016/j.actbio.2022.07.053Mimicking tumor microenvironment by 3D bioprinting: 3D cancer modeling, Article 032002. Shukla, P., Yeleswarapu, S., Heinrich, M. A., Prakash, J. & Pati, F.https://doi.org/10.1088/1758-5090/ac6d11Targeting of macrophages and hepatic stellate cells for the treatment of liver diseases. University of Twente. Kurniawan, D. W.https://doi.org/10.3990/1.9789036553445Impact of endotoxins on bioengineered tissues and models, 532-534. Heinrich, M. A., Mangia, M. & Prakash, J.https://doi.org/10.1016/j.tibtech.2021.12.001Designing novel therapeutic strategies against tumor stroma and fibrosis. University of Twente. Mardhian, D. F.https://doi.org/10.3990/1.9789036553179Src kinase as a potential therapeutic target in non-alcoholic and alcoholic steatohepatitis, Article e18. Kurniawan, D. W., Booijink, R. S., Jajoriya, A. K., Dhawan, G., Mishra, D., Oosterhuis, D., Argemi, J., Storm, G., Olinga, P., Bataller, R., Mohanty, S. K., Mishra, D. P., Prakash, J. & Bansal, R.https://doi.org/10.1002/ctd2.18Engineering the tumor microenvironment: Novel 3D in vitro models to study cellular interactions & therapeutics. University of Twente. Heinrich, M. A.https://doi.org/10.3990/1.9789036553162The Tumor Stroma: Biology and Therapeutics. Prakash, J.https://doi.org/10.1201/97810032249213D in vitro Models to Mimic the Tumor MicroenvironmentIn The Tumor Stroma: Biology and Therapeutics. Taylor & Francis. Alexander, M., Huynh, N. T., Zhang, Y. S. & Prakash, J.https://doi.org/10.1201/9781003224921-10

Onderzoeksprofielen

Verbonden aan opleidingen

Vakken collegejaar 2023/2024

Vakken in het huidig collegejaar worden toegevoegd op het moment dat zij definitief zijn in het Osiris systeem. Daarom kan het zijn dat de lijst nog niet compleet is voor het gehele collegejaar.

Vakken collegejaar 2022/2023

In de pers

Volkskrant Newspaper (Sep 2019): Verzwakte muur om kankercellen biedt chemo een kans. https://www.volkskrant.nl/cs-bf0bd786

Tubantia Newspaper,   “UT sets new steps in the treatment of pancreatic cancer”, 10 Nov 2017. https://www.tubantia.nl/regio/ut-zet-flinke-stappen-in-behandeling-alvleesklierkanker~a2caecdc/

U-Today, Science and Technology magazine  “Novel treatment to kill cancer by targeting stroma” Oct, 2017. https://www.utoday.nl/science/64599/unique-treatment-from-twente-effectively-kills-cancer

“KNCV Golden Master award 2017” to Marcel Heinrich (PhD student under my supervision), for his master project in my group on "Lipids against Cancer". https://www.c2w.nl/verenigingen-8751/lipide-tegen-kanker/item19184

Nieuws op utwente.nl

Perspectief Op Effectievere Behandeling Alsvleesklierkanker

https://www.utwente.nl/nieuws/2019/9/512858/perspectief-op-effectievere-behandeling-alvleesklierkanker

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