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prof.dr. J. Prakash (Jai)

Hoogleraar - Engineered Therapeutics

Expertises

Chemistry
Antifibrotic
Stellate Crystal
Medicine & Life Sciences
Fibrosis
Hepatic Stellate Cells
Liver Cirrhosis
Nanoparticles
Neoplasms
Pancreatic Stellate Cells

Publicaties

Recent
Prakash, J. (2021). Integrin binding peptide and use of the same. (Patent No. JP2021101719).
Heinrich, M. A. , Mostafa, A. M. R. H., Morton, J. P., Hawinkels, L. J. A. C. , & Prakash, J. (2021). Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models. Advanced drug delivery reviews, 174, 265-293. https://doi.org/10.1016/j.addr.2021.04.018
Mostafa, A. M. R. H. , Bansal, R. , & Prakash, J. (2020). Targeting Fibroblasts in Fibrosis and Cancer. In J. Brenneman, & M. R. Iyer (Eds.), Anti-fibrotic Drug Discovery (pp. 307-339). (RSC Drug Discovery Series; Vol. 2020-January, No. 73). Royal Society of Chemistry. https://doi.org/10.1039/9781788015783-00307
Schnittert, J. , Bansal, R. , Mardhian, D. F., van Baarlen, J., Östman, A. , & Prakash, J. (2019). Integrin α11 in pancreatic stellate cells regulates tumor stroma interaction in pancreatic cancer. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(5), 6609-6621. https://doi.org/10.1096/fj.201802336R
Heinrich, M. A., Liu, W., Jimenez, A., Yang, J., Akpek, A., Liu, X., Pi, Q., Mu, X., Hu, N., Schiffelers, R. M. , Prakash, J., Xie, J., & Zhang, Y. S. (2019). 3D Bioprinting: from Benches to Translational Applications. Small, 15(23), [1805510]. https://doi.org/10.1002/smll.201805510
Akcora, B. Ö., Dathathri, E. , Ortiz-Perez, A. , Gabriël, A. V. , Storm, G. , Prakash, J. , & Bansal, R. (2019). TG101348, a selective JAK2 antagonist, ameliorates hepatic fibrogenesis in vivo. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(8), 9466-9475. https://doi.org/10.1096/fj.201900215RR
Kuninty, P. R. , Bansal, R., De Geus, S. W. L. , Mardhian, D. F. , Schnittert, J., van Baarlen, J. , Storm, G., Bijlsma, M. F., van Laarhoven, H. W. , Metselaar, J. M., Kuppen, P. J. K., Vahrmeijer, A. L., Östman, A., Sier, C. F. M. , & Prakash, J. (2019). ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer. Science advances, 5(9), [eaax2770]. https://doi.org/10.1126/sciadv.aax2770
Roovers, S., Deprez, J. , Priwitaningrum, D. , Lajoinie, G. , Rivron, N., Declercq, H., De Wever, O., Stride, E. , Le Gac, S. , Versluis, M. , Prakash, J., De Smedt, S. C., & Lentacker, I. (2019). Sonoprinting liposomes on tumor spheroids by microbubbles and ultrasound. Journal of controlled release, 316, 79-92. https://doi.org/10.1016/j.jconrel.2019.10.051
Kurniawan, D. W., Jajoriya, A. K., Dhawan, G., Mishra, D. P. , Storm, G., Mishra, D. , Prakash, J. , & Bansal, R. (2018). Therapeutic inhibition of SYK kinase in macrophages using PLGA nanoparticles for the treatment of non-alcoholic steatohepatitis. 546. Poster session presented at 26th United European Gastroenterology Week Vienna 2018, Vienna, Austria. https://doi.org/10.1177/2050640618792832
Kurniawan, D. W., Dhawan, G., Oosterhuis, D. , Storm, G., Olinga, P., Mishra, D. P. , Prakash, J. , & Bansal, R. (2018). PLGA nanoparticles-based delivery of SRC kinase signaling pathway inhibitor KX2-391 for the treatment of non-alcoholic steatohepatitis. 545. Poster session presented at 26th United European Gastroenterology Week Vienna 2018, Vienna, Austria. https://doi.org/10.1177/2050640618792832

Google Scholar Link

In de Pers

Volkskrant Newspaper (Sep 2019): Verzwakte muur om kankercellen biedt chemo een kans. https://www.volkskrant.nl/cs-bf0bd786

Tubantia Newspaper,   “UT sets new steps in the treatment of pancreatic cancer”, 10 Nov 2017. https://www.tubantia.nl/regio/ut-zet-flinke-stappen-in-behandeling-alvleesklierkanker~a2caecdc/

U-Today, Science and Technology magazine  “Novel treatment to kill cancer by targeting stroma” Oct, 2017. https://www.utoday.nl/science/64599/unique-treatment-from-twente-effectively-kills-cancer

“KNCV Golden Master award 2017” to Marcel Heinrich (PhD student under my supervision), for his master project in my group on "Lipids against Cancer". https://www.c2w.nl/verenigingen-8751/lipide-tegen-kanker/item19184

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Universiteit Twente
Drienerlolaan 5
7522 NB Enschede

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Universiteit Twente
Postbus 217
7500 AE Enschede

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