Welkom...

dr. K. Broersen (Kerensa)

Universitair hoofddocent

Expertises

Alzheimer Disease
Peptides
Amyloid Beta-Peptides
Cerebral Amyloid Angiopathy
Amyloid
Poisons
Agglomeration
In Vitro Techniques

Publicaties

Recente Artikelen
Teodorowicz, M., Perdijk, O., Verhoek, I., Govers, C., Savelkoul, H. F. J., Tang, Y., ... Broersen, K. (2017). Optimized triton X-114 assisted lipopolysaccharide (LPS) removal method reveals the immunomodulatory effect of food proteins. PLoS ONE, 12(3), [0173778]. DOI: 10.1371/journal.pone.0173778
Ruzafa, D., Hernandez-Gomez, Y. S., Bisello, G., Broersen, K., Morel, B., & Conejero-Lara, F. (2017). The influence of N-terminal acetylation on micelle-induced conformational changes and aggregation of α-Synuclein. PLoS ONE, 12(5), [e0178576]. DOI: 10.1371/journal.pone.0178576
Hubin, E., Cioffi, F., Rozenski, J., Van Nuland, N. A. J., & Broersen, K. (2016). Characterization of insulin-degrading enzyme-mediated cleavage of Aβ in distinct aggregation states. Biochimica et biophysica acta. General subjects, 1860(6), 1281-1290. DOI: 10.1016/j.bbagen.2016.03.010
Hubin, E., Vanschoenwinkel, B., Broersen, K., de Deyn, P. P., Koedam, N., van Nuland, N., & Pauwels, K. (2016). Could ecosystem management provide a new framework for Alzheimer's disease?Alzheimer's & dementia, 12(1), 65-74. DOI: 10.1016/j.jalz.2015.07.491
Barrera Guisasola, E. E., Andujar, S., Hubin, E., Broersen, K., Kraan, Y. M., Mendez, L., ... Enriz, R. D. (2015). New mimetic peptides inhibitors of Aβ aggregation: Molecular guidance for rational drug design. European journal of medicinal chemistry, 95, 136-152. DOI: 10.1016/j.ejmech.2015.03.042
Hubin, E., de Roo, S., Schierle, G. K., Kaminski, C., Serpell, L. C., Subramaniam, V., ... Sarroukh, R. (2015). Two distinct Beta-sheet structures in Italian-mutant amyloid-beta fibrils: a potential link to different clinical phenotypes. Cellular and Molecular Life Sciences, 72(24), 4899-4913. DOI: 10.1007/s00018-015-1983-2
Cioffi, F., Rodriguez, A. M., Masman, M. F., Enriz, R. D., & Broersen, K. (2015). The multifactorial character of Alzheimer's disease. -. Poster session presented at MIRA Institute for Biomedical Technology and Technical Medicine Day, Enschede, .
Hubin, E., Cioffi, F., Rozenski, J., van Nuland, N., & Broersen, K. (2015). Characterization of insulin-degrading enzyme-mediated cleavage of Abeta in distinct aggregation stages. -. Poster session presented at Dutch BioPhysics meeting, Lunteren, .
Verhoek, I., Teodorowicz, G., Wichers, H., & Broersen, K. (2015). Structural and immunogenic characterization of differently organized bovine Beta-lactoglobulin aggregates. -. Poster session presented at 9th NIZO Dairy Conference, Arnhem, Papendal, .
Hubin, E., van Nuland, N., Broersen, K., & Pauwels, K. (2014). Transient dynamics of Abeta contribute to toxicity in Alzheimer's disease. Cellular and Molecular Life Sciences, 71(18), 3507-3521. DOI: 10.1007/s00018-014-1634-z
Adrover, M., Marino, L., Sanchis, P., Pauwels, K., Kraan, Y. M., Lebrun, P., ... Donoso, J. (2014). Mechanistic insights in glycation-induced protein aggregation. Biomacromolecules, 15(9), 3449-3462. DOI: 10.1021/bm501077j
Barrera, E., Salcedo, R., Hubin, E., Broersen, K., Andujar, S., & Rodriguez, E. R. (2014). New mimetic peptide inhibitors of Abeta-aggregation. Molecular guidance for rational drug design. -. Poster session presented at Congress of the World Association of Theoretical and Computational Chemists WATOC 2014, Santiago, Chili, .
Sarroukh, R., Hubin, E., Serpell, L. C., van Nuland, N., Broersen, K., & Raussens, V. (2014). Alzheimer's disease and cerebral amyloid angiopathy, doppelgangers?. 86-. Abstract from The 28th Annual Symposium of The Protein Society, .DOI: 10.1002/pro.2504
Hubin, E., Sarroukh, R., de Roo, S., Raussens, V., van Nuland, N., & Broersen, K. (2013). Antiparallel beta-sheet architecture of italian-mutant amyloid-beta fibrils. -. Poster session presented at Spetsai Summer School on Protein Interactions, assesmblies and human disease, Spetses, Greece, .
Hubin, E., Sarroukh, R., de Roo, S., Raussens, V., van Nuland, N., & Broersen, K. (2013). Antiparallel beta-sheet architecture of italian-mutant amyloid-beta fibrils. -. Poster session presented at TN2 Conference on Alzheimer's disease and related disorders, Amsterdam, .
Vandersteen, A., Masman, M. F., de Baets, G., Jonckheere, W., van der Werf, K., Marrink, S. J., ... Broersen, K. (2012). Molecular plasticity regulates oligomerization and cytotoxicity of the multi-peptide length Abeta pool. Journal of biological chemistry, 287(44), 36732-36743. [36732]. DOI: 10.1074/jbc.M112.394635
Pauwels, K., Williams, T. L., Morris, K. L., Jonckheere, W., Vandersteen, A., Kelly, G., ... Broersen, K. (2012). The structural basis for increased toxicity of pathological Abeta42:Abeta40 ratios in Alzheimer's disease. Journal of biological chemistry, 287, 5650-5660. DOI: 10.1074/jbc.M111.264473
Vandersteen, A., Hubin, E., Sarroukh, R., de Baets, G., Schymkowitz, J., Rousseau, F., ... Broersen, K. (2012). A comparative analysis of the aggregation behavior of amyloid-beta peptide variants. FEBS letters, 586(23), 4088-4093. DOI: 10.1016/j.febslet.2012.10.022
Hubin, E., Rozenski, J., De Strooper, B., Subramaniam, V., van Nuland, N., & Broersen, K. (2012). Effect of ApoE isoform and lipidation status on proteolytic clearance of Amyloid-beta peptide. -. Poster session presented at ApoE, Alzheimer's disease and Lipoprotein Biology, Keystone symposia, Colorado, USA, .
Hubin, E., Rozenski, J., Subramaniam, V., van Nuland, N., & Broersen, K. (2012). Effect of ApoE isoform and lipidation status on proteolytic clearance of the Amyloid-beta peptide. -. Poster session presented at NVMS-BSMS International Congress on Mass Spectrometry, Rolduc, .

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Contactgegevens

Bezoekadres

Universiteit Twente
Faculteit Technische Natuurwetenschappen
Horst - Zuidhorst (gebouwnr. 28), kamer 155
De Horst 2
7522LW  Enschede

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Postadres

Universiteit Twente
Faculteit Technische Natuurwetenschappen
Horst - Zuidhorst  155
Postbus 217
7500 AE Enschede

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