dr. K. Broersen (Kerensa)

Faculty of Science and Technology (TNW), Applied Stem Cell Technologies (AST)

NIZO
Project leader at NIZO food research

Koch, L. S., Buentello, D. C. , & Broersen, K. (2023). Robust Tissue Fabrication for Long-Term Culture of iPSC-Derived Brain Organoids for Aging Research. Journal of visualized experiments, 2023(195), Article e64586. https://doi.org/10.3791/64586

Passeri, E., Elkhoury, K., Morsink, M. , Broersen, K., Linder, M., Tamayol, A., Malaplate, C., Yen, F. T., & Arab-Tehrany, E. (2022). Alzheimer’s Disease: Treatment Strategies and Their Limitations. International journal of molecular sciences, 23(22), Article 13954. https://doi.org/10.3390/ijms232213954

Buentello, D. C. , Koch, L. S., Trujillo-De Santiago, G., Alvarez, M. M. , & Broersen, K. (2022). Use of standard U-bottom and V-bottom well plates to generate neuroepithelial embryoid bodies. PLoS ONE, 17(5 May), Article e0262062. https://doi.org/10.1371/journal.pone.0262062

Borges, A. C. , Broersen, K., Leandro, P., & Fernandes, T. G. (2022). Engineering Organoids for in vitro Modeling of Phenylketonuria. Frontiers in Molecular Neuroscience, 14, Article 787242. https://doi.org/10.3389/fnmol.2021.787242

Zakharova, M. (2022). Engineering a multiplexed Blood-Brain Barrier-on-a-chip. [PhD Thesis - Research UT, graduation UT, University of Twente]. University of Twente. https://doi.org/10.3990/1.9789036554299

Cioffi, F., Adam, R. H. I. , Bansal, R. , & Broersen, K. (2021). A review of oxidative stress products and related genes in early alzheimer's disease. Journal of Alzheimer's Disease, 83(3), 977-1001. https://doi.org/10.3233/JAD-210497

Zakharova, M. , Tibbe, M. P. , Koch, L. S. , Le-The, H. , Leferink, A. M. , van den Berg, A. , van der Meer, A. D. , Broersen, K. , & Segerink, L. I. (2021). Transwell-Integrated 2 µm Thick Transparent Polydimethylsiloxane Membranes with Controlled Pore Sizes and Distribution to Model the Blood-Brain Barrier. Advanced Materials Technologies, 6(12), Article 2100138. Advance online publication. https://doi.org/10.1002/admt.202100138

Vaneyck, J. , Segers-Nolten, I. , Broersen, K. , & Claessens, M. M. A. E. (2021). Cross-seeding of alpha-synuclein aggregation by amyloid fibrils of food proteins. Journal of biological chemistry, 296, Article 100358. https://doi.org/10.1016/J.JBC.2021.100358

Marasco, D., Vicidomini, C., Krupa, P. , Cioffi, F., Huy, P. D. Q., Li, M. S., Florio, D. , Broersen, K., De Pandis, M. F., & Roviello, G. N. (2021). Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo[c]phenanthridine and berberine-based compounds on β-amyloid aggregation. Chemico-Biological Interactions, 334, Article 109300. Advance online publication. https://doi.org/10.1016/j.cbi.2020.109300

Broersen, K. (2020). Detection of amyloid aggregation in living systems. In Protein Homeostasis Diseases: Mechanisms and Novel Therapies (pp. 127-152). Elsevier. https://doi.org/10.1016/B978-0-12-819132-3.00007-5

Broersen, K. (2020). Milk processing affects structure, bioavailability and immunogenicity of β-lactoglobulin. Foods, 9(7), Article 874. https://doi.org/10.3390/foods9070874

Zakharova, M., Palma do Carmo, M. A. , van der Helm, M. W. , Le-The, H., de Graaf, M. N. S., Orlova, V. , van den Berg, A. , van der Meer, A. D. , Broersen, K. , & Segerink, L. I. (2020). Multiplexed blood-brain barrier organ-on-chip. Lab on a chip, 20(17), 3132-3143. https://doi.org/10.1039/d0lc00399a

Claes, F., Rudyak, S., Laird, A. S., Louros, N., Beerten, J., Debulpaep, M., Michiels, E., van der Kant, R., Van Durme, J., De Baets, G., Houben, B., Ramakers, M., Yuan, K., Gwee, S. S. L., Hernandez, S. , Broersen, K., Oliveberg, M., Moahamed, B., Kirstein, J., ... Schymkowitz, J. (2019). Exposure of a cryptic Hsp70 binding site determines the cytotoxicity of the ALS-associated SOD1-mutant A4V. Protein engineering, design & selection : PEDS, 32(10), 443-457. https://doi.org/10.1093/protein/gzaa008

Zakharova, M. , van der Helm, M., do Carmo, M. P. , Le-The, H. , Tibbe, M. , van der Meer, A. , Broersen, K. , Eijkel, J. , & Segerink, L. (2019). Multiplexed organ-on-chip device for increased throughput analysis of the tissue barrier function. In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 (pp. 432-433). The Chemical and Biological Microsystems Society.

Zakharova, M. , van der Helm, M., Palma Do Carmo, M. , Le The, H. , Tibbe, M. , van der Meer, A. , Broersen, K. , Eijkel, J. , & Segerink, L. (2019). Multiplexed organ-on-chip device for increased throughput analysis of the tissue barrier function. Poster session presented at 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019, Basel, Switzerland.

Cioffi, F., Adam, R. H. I. , & Broersen, K. (2019). Molecular Mechanisms and Genetics of Oxidative Stress in Alzheimer's Disease. Journal of Alzheimer's Disease, 72(4), 981-1017. https://doi.org/10.3233/JAD-190863

Cioffi, F. (2019). Investigation into the molecular complexity of Alzheimer's disease: an amyloid-ß centered approach. [PhD Thesis - Research UT, graduation UT, University of Twente]. University of Twente. https://doi.org/10.3990/1.9789036548410

Hubin, E., Verghese, P. B., van Nuland, N. , & Broersen, K. (2019). Apolipoprotein E associated with reconstituted high-density lipoprotein-like particles is protected from aggregation. FEBS letters, 593(11), 1144-1153. Advance online publication. https://doi.org/10.1002/1873-3468.13428

Vicidomini, C. , Cioffi, F. , Broersen, K., Roviello, V., Riccardi, C., Montesarchio, D., Capasso, D., Gaetano, S. D., Musumeci, D., & Roviello, G. N. (2019). Benzodifurans for biomedical applications: BZ4, a selective anti-proliferative and anti-amyloid lead compound. Future Medicinal Chemistry, 11(4), 285-302. https://doi.org/10.4155/fmc-2018-0473

Gera, J., Szögi, T., Bozsó, Z., Fülöp, L., Barrera, E. E., Rodriguez, A. M., Méndez, L., Delpiccolo, C. M. L., Mata, E. G. , Cioffi, F. , Broersen, K., Paragi, G., & Enriz, R. D. (2018). Searching for improved mimetic peptides inhibitors preventing conformational transition of amyloid-β₄₂ monomer. Bioorganic Chemistry, 81, 211-221. https://doi.org/10.1016/j.bioorg.2018.08.018

Broersen, K., Ruipérez, V., & Davletov, B. (2018). Structural and aggregation properties of Alpha-Synuclein linked to phospholipase A2 action. Protein and Peptide Letters, 25(4), 368-378. https://doi.org/10.2174/0929866525666180326120052

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Bachelor

Vakken in het huidig collegejaar worden toegevoegd op het moment dat zij definitief zijn in het Osiris systeem. Daarom kan het zijn dat de lijst nog niet compleet is voor het gehele collegejaar.